ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0017.14-12 | (1) | ESPEYB17

14.12. Brain-Sparing sympathofacilitators mitigate obesity without adverse cardiovascular effects

I Mahu , A Barateiro , E Rial-Pensado , N Martinez-Sanchez , SH Vaz , PMSD Cal , B Jenkins , T Rodrigues , C Cordeiro , MF Costa , R Mendes , E Seixas , MMA Pereira , N Kubasova , V Gres , I Morris , C Temporao , M Olivares , Y Sanz , A Koulman , F Corzana , AM Sebastiao , M Lopez , GJL Bernardes , AI Domingos

To read the full abstract: Cell Metab. 2020 Jun 2;31(6):1120-1135.e7. doi: 10.1016/j.cmet.2020.04.013.This experimental rodent study of a PEGylated amphetamine (PEGyAMPH) designed to not cross the blood brain barrier is interesting for 2 reasons. First, it shows that its peripheral anti-obesity effects alone (without the central anorexic effects of amphetamine) are sufficient to achieve...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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